L.W. Chan. Advances in activity-based diagnostics for infectious disease and microbiome health. Curr. Opin. Biomed. In press.
L. W. Chan, K. E. Hern, C. Ngambenjawong, K. Lee, E. J. Kwon, D. T. Hung, S. N. Bhatia. Selective permeabilization of Gram-negative bacterial membranes using multivalent peptide constructs for antibiotic sensitization. ACS Infect. Dis. 7, 721-732 (2021).
B. Kim, Q. Yang, L. W. Chan, S. N. Bhatia, E. Ruoslahti, M. J. Sailor. Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections. Nanoscale Horiz. 6, 330-340 (2021).
L. W. Chan, M. N. Anahtar, T. H. Ong, K. E. Hern, R. R. Kunz, S. N. Bhatia. Engineering synthetic breath biomarkers for respiratory disease. Nat. Nanotechnol. 15, 792-800 (2020).
L. W. Chan, N. J. White, S. H. Pun. A fibrin cross-linking polymer enhances clot formation similar to factor concentrates and tranexamic acid in an in vitro model of coagulopathy. ACS Biomater. Sci. Eng. 2, 403-408 (2016).
L. W. Chan, X. Wang, H. Wei, L. D. Pozzo, N. J. White, S. H. Pun. A synthetic fibrin-crosslinking polymer for modulating clot properties and inducing hemostasis. Sci. Transl. Med. 7, 277ra29 (2015). *Front cover
L. W. Chan, N. J. White, S. H. Pun, Synthetic strategies for engineering intravenous hemostats. Bioconjug. Chem. 26, 1224–1236 (2015).
L. W. Chan, C. H. Kim, X. Wang, S. H. Pun, N. J. White, T. H. Kim. PolySTAT-modified chitosan gauzes for improved hemostasis in external hemorrhage. Acta Biomaterialia 31, 178-85 (2015).
H. Wei, L. R. Volpatti, D. L. Sellers, D. O. Maris, I. W. Andrews, A. S. Hemphill, L. W. Chan, D. S. H. Chu, P. J. Horner, S. H. Pun. Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angew. Chemie 52, 5377–5381 (2013).
L. W. Chan, Y. Wang, L. Y. Lin, M. P. Upton, J. H. Hwang, S. H. Pun. Synthesis and characterization of anti-EGFR fluorescent nanoparticles for optical molecular imaging. Bioconjug. Chem. 24, 167–175 (2012).
C. K. Wang, L. W. Chan, R. N. Johnson, D. S. H. Chu, J. Shi, J. G. Schellinger, A. Lieber, S. H. Pun. The transduction of coxsackie and adenovirus receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus. Biomaterials 32, 9536– 9545 (2012).
E. Karathanasis, C. M. Geigerman, C.A. Parkos, L. Chan, R.V. Bellamkonda, D.L. Jaye, Selective targeting of nanocarriers to neutrophils and monocytes. Ann. Biomed. Eng. 37, 1984–1992 (2009).
E. Karathanasis, L. Chan, L. Karumbaiah, K. McNeeley, C. J. D’Orsi, A. V. Annapragada, I. Sechopoulos, R. V. Bellamkonda. Tumor vascular permeability to a nanoprobe correlates to tumorspecific expression levels of angiogenic markers. PLoS One 4, e5843 (2009).
E. Karathanasis, L. Chan, S. R. Balusu, C. J. D’Orsi, A. V Annapragada, I. Sechopoulos, R. V Bellamkonda, Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy. Biomaterials 29, 4815–22 (2008).
Bhatia SN, Chan LW, Anahtar MN & MIT, Inhalable nanosensors with volatile reporters and uses thereof, pending.
Bhatia SN, Kwon EJ, Chan LW & MIT, Antimicrobial constructs and uses thereof, pending.
Pun SP, Chan LW, White NJ & UW 2019, Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders, 10,231,993.
2019 – 2023
2018 – 2019
2013 – 2015
2012 – 2013
NIH K99/R00 Pathway to Independence Award
BMES Career Development Award
Bioengineering Cardiovascular Training Grant Fellowship (T32)
Nanotechnology and Physical Science in Cancer Research Fellowship (T32)